Yago Margolles

This study identifies plasmid-encoded proteins with immunoglobulin-like domains as targets for combating antimicrobial resistance by generating nanobodies that block plasmid conjugation.

This study demonstrates how ssDNA recombineering in bacteria enables hyper-diversification of nanobodies, resulting in variants that recognize new antigens while retaining original specificity.

The paper describes the development of a high-affinity Nanobody against SARS-CoV-2 RBD that neutralizes wild-type and D614G variants with nanomolar potency.