David G. Amaral

This study identifies persistent excitatory neuron dysfunction in Chd8 haploinsufficient mice through single nucleus transcriptomics and behavioral analysis.

The paper investigates cellular mechanisms of brain overgrowth in autistic children with megalencephaly, finding elevated GPX4 and resistance to ferroptosis in neural progenitor cells.

This study identifies 135 ASD-associated protein-coding genes using whole-genome sequencing data from 11,312 individuals and exome sequencing from over 18,000 trios, with a false discovery rate of 80%.

The paper investigates whether increased cortical volume in Chd8 mutant mice is due to increased neuron number or soma size, finding no increase in neuron number but increased volume.

This study examines the effects of maternal immune activation on neurobehavioral development in rhesus monkey offspring, finding reduced gray matter volume in specific brain regions.