Chd8 haploinsufficiency leads to molecular layer heterotopias and age-dependent cortical expansion
Felix A. Kyere, Ian Curtin, Ziquan Wei, César P. Canales, Nicolas Seban, Lei Xing, Preslava P Todorova, Leticia Pérez-Sisqués, Maya Yilan Yin, Tao Wen, Roza Vlasova, Dirgha Sheth, Jeffrey Bennett, Kejia Li, Nana Matoba, , Jason L. Stein
This study identifies molecular layer heterotopias and age-dependent cortical expansion in Chd8 haploinsufficient mice, linking them to neuronal migration defects and autism-related brain overgrowth.
bioRxiv · Jun 22, 2026 · PreprintNeuroscience