Proximity-labeling proteomics reveals remodeled interactomes and altered localization of pathogenic SHP2 variants
Anne E. van Vlimmeren, Lauren C. Tang, Ziyuan Jiang, Abhishek Iyer, Rashmi Voleti, Konstantin Krismer, Jellert T. Gaublomme, Marko Jovanović, Neel H. Shah
This study uses proximity-labeling proteomics to analyze how SHP2 mutations alter its interactome and localization, revealing functional consequences of different mutation types.
EMBO Reports · Dec 22, 2025Peer-reviewedMolecular Biology