Jellert T. Gaublomme

The paper presents the Human Gut Cell Atlas v1.0, a unified reference of gut cell diversity, revealing how tissue structure influences cellular composition and enabling disease and organoid analysis.

This study uses proximity-labeling proteomics to analyze how SHP2 mutations alter its interactome and localization, revealing functional consequences of different mutation types.

The paper shows that most axonal mitochondria in mammalian neurons lack mtDNA and do not produce ATP, contrasting with dendritic mitochondria.

CRISPRmap enables multi-omic optical pooled screens to map gene function in cells and tissue without sequencing, identifying pathogenic mutations and analyzing spatial phenotypes.

The paper introduces a method to multiplex single-nucleus RNA-seq using barcoded antibodies, reducing costs and enabling large-scale studies.