Author

Christopher D. McFarland

Case Comprehensive Cancer CenterORCID 0000-0002-6901-4035Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

Adam M. KresakiD· 1 shared Athar KhaliliD· 1 shared Berkley E. GryderiD· 1 shared Jacob G. ScottiD· 1 shared Jeff MaltasiD· 1 shared Madeline BedrockiD· 1 shared Meaghan ParksiD· 1 shared Michael HinczewskiiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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1 shared paperCancer Biology

Adam M. KresakORCID

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2 papers

Recent·Most cited

Can public good producing subclones invade a population of non-producers?

Svyatoslav Tkachenko, Michael Hinczewski, Christopher D. McFarland

The paper shows that public good-producing subclones can invade non-producer populations in structured environments due to spatial effects, challenging classical evolutionary game theory predictions.

bioRxiv · May 16, 2026 · PreprintEvolutionary Biology

In Vivo Multiplexed Modeling Reveals Diverse Roles of the TBX2 Subfamily and Egr1 in Ras-Driven Lung Adenocarcinoma

Athar Khalil, Trang Dinh, Meaghan Parks, Rebecca C. Obeng, Berkley E. Gryder, Adam M. Kresak, Yuxiang Wang, Jeff Maltas, Madeline Bedrock, Xiangzhen Wei, Zachary J. Faber, Mira Rahm, Jacob G. Scott, Thomas LaFramboise, Zhenghe Wang, Christopher D. McFarland

The paper develops a multiplexed mouse model to study TBX2 subfamily and Egr1 roles in Ras-driven lung cancer, finding Egr1 loss significantly increases tumor size and suggests immune dysregulation.

Genes & Diseases · Sep 3, 2025Peer-reviewedCancer Biology