Author

Shannon S. Lu

University of ChicagoORCID 0000-0003-1556-7520Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:benchmarking· 1 Approach:contrastive learning· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Assay:protein sequence· 1 Assay:protein structure· 1 Approach:statistical model· 1

Frequent Co-Authors

Bryan C. DickinsoniD· 2 shared Christopher BasileiD· 2 shared Joshua A. PixleyiD· 2 shared Matthew J. StylesiD· 2 shared Aaron R. DinneriD· 1 shared Aditya NandyiD· 1 shared Cheng Frank GaoiD· 1 shared Siyuan Tao· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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2 shared papersSynthetic Biology

Bryan C. DickinsonORCID

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2 papers

Recent·Most cited

Synthetic BiologybioRxivPreprintOct 14, 2025

Mapping the diverse topologies of protein-protein interaction fitness landscapes

Shannon S. Lu, Matthew J. Styles, Cheng Frank Gao…·Bryan C. Dickinson

The paper identifies target-specific fitness landscapes in protein-protein interactions and develops a supervised contrastive learning approach to predict binders.

2 citations

protein sequencestatistical model

𝕏 PostBluesky

Synthetic BiologybioRxivPreprintJan 6, 2025

High-throughput protein binder discovery by rapid in vivo selection

Matthew J. Styles, Joshua A. Pixley, Tongyao Wei…·Bryan C. Dickinson

This paper introduces PANCS-binders, an in vivo selection method for discovering protein binders, and demonstrates its ability to screen billions of variants against multiple targets in two days.

4 citations

protein structureexperimental assay

𝕏 PostBluesky