PJ Michael Deans

The paper evaluates estradiol's effects on ASD/NDD genes using human neurons and zebrafish, finding both convergent transcriptomic effects and gene-specific cellular and behavioral rescue.

The paper identifies a pro-plasticity program in spared corticospinal neurons after partial CNS injury and validates strategies to enhance neurite regeneration.

This study shows BRD1 haploinsufficiency disrupts early neuronal programming and synaptic maturation in human induced glutamatergic neurons, leading to altered neurodevelopmental trajectories and increased neuronal activity.

The paper maps 3D chromatin structures in neuronal subtypes and shows how schizophrenia risk loci reorganize during differentiation, linking regulatory loops to gene function.

The paper shows that non-additive effects of schizophrenia risk genes are due to convergent downstream transcriptomic effects and sub-additive changes, suggesting functional redundancy as a mechanism for non-additivity.

This study shows that schizophrenia risk genes have convergent and non-additive transcriptomic effects when perturbed together in human neurons, suggesting functional redundancy and complex interactions.