The mammalian-adaptive PB2-E627K substitution preserves viral fitness of clade 2.3.4.4b H5N1 HPAIV in birds.
Elizabeth Billington, Sofia Riccio, Maryn D. Brown…·Joe James
This study shows that the mammalian-adaptive PB2-E627K mutation in H5N1 HPAIV maintains viral fitness in avian hosts, increasing zoonotic risk.