Maryn D. Brown

This study shows that the mammalian-adaptive PB2-E627K mutation in H5N1 HPAIV maintains viral fitness in avian hosts, increasing zoonotic risk.

This study identifies host proteins co-opted by influenza A virus polymerase for transcription or replication using differential interactome screening.

Cattle B3.13 H5N1 polymerase gained PB2 M631L and PA K497R, boosting replication in bovine and human cells via better bovine ANP32A use; later PB2 E627K and D740N add activity.