Karina Sharma

Central Glucagon-Like Peptide-1 Agonism Ameliorates Colonic Inflammation in a Murine Model of Inflammatory Bowel Disease

This study shows that central GLP-1 receptor activation reduces colonic inflammation in a mouse model of IBD, independent of peripheral effects.

EGFR INHIBITION PROMOTES ENTEROENDOCRINE CELL DIFFERENTIATION CONTRIBUTING TO TREATMENT-ASSOCIATED DIARRHEA

This study identifies EGFR inhibitors as inducers of enteroendocrine cell differentiation, linking their use to treatment-associated diarrhea through STAT1 signaling activation.

Blautia wexlerae Transforms Dietary Fatty Acids to Activate Enteroendocrine Signaling and Improve Metabolic Health in Mice and Humans

This study identifies Blautia wexlerae's role in converting dietary fats into bioactive metabolites that enhance gut hormone secretion and improve metabolic health in mice and humans.

Clonal memory of colitis accumulates and promotes tumor growth

The paper shows that colitis leaves an epigenetic memory in colonic stem cells that promotes tumor growth by enhancing regenerative gene programs and AP-1 activity.