Fulton T. Crews

This study identifies a distinct reactive microglial phenotype in human AUD that activates astrocytes, contributing to neurodegeneration and heavy drinking.

This study shows adolescent binge ethanol exposure leads to lasting alcohol tolerance in adulthood, mediated by proinflammatory HMGB1 signaling, and that blocking HMGB1 reverses this tolerance.

This study shows that TLR3 agonism increases alcohol consumption in rats, with females being more sensitive to lower doses than males.

This study shows that TLR7 activation with imiquimod increases ethanol self-administration and induces TLR-related gene expression in rats, with sex-specific effects on drinking behavior and molecular responses.

This study examines how adolescent intermittent ethanol exposure affects interneurons and perineuronal nets in the adult prefrontal cortex and striatum, finding increased perineuronal nets without changes in interneuron numbers.