William F. Forrest

Fishash assigns perturbations to cells in Perturb-seq data using Fisher's Exact Test, improving accuracy and speed over existing methods.

This paper improves Perturb-seq by analyzing guide multiplets, reducing costs and maintaining signal recovery.

This study evaluates bifunctional ER degraders with different ubiquitin ligase ligands, finding that pan-IAP antagonists enhance ER degradation and induce TNF-dependent cell death more effectively than existing therapies.

MiDAS is an R package that enables statistical analysis of immunogenetic data, including HLA fine mapping, evolutionary divergence, and HLA-KIR interactions.

The paper analyzes how multi-target sgRNAs in CRISPR screens introduce biases in essentiality scores and functional networks.