Paul Franken

The paper shows that vagal afferent activation induces brain-body cooling and NREM-sleep-like states while increasing locus coeruleus activity.

The paper develops a model to integrate circadian and sleep-wake influences on gene expression, revealing tissue-specific regulatory effects and desynchronization after sleep deprivation.

This study shows that miR-709 regulates NREM sleep EEG slow waves by linking glutamatergic signaling to neuronal activity through endosomal trafficking.

The paper evaluates the impact of reference bias on transcriptome and eQTL analysis in mouse genetic studies and proposes improved reference strategies.

The paper develops a model to predict brain temperature in mice based on sleep-wake state and time-of-day, finding sleep-wake sequences explain most of the variance.

The paper re-evaluates slow-wave dynamics as a proxy for NREM sleep homeostasis, finding distinct delta-wave types with different responses to sleep deprivation and recovery.

The paper shows that direct photic effects and circadian-driven effects equally shape the sleep-wake cycle in mice, with melanopsin mediating most direct light effects.

This study examines how sleep deprivation affects gene expression and chromatin accessibility in mice, revealing long-term genomic regulatory changes.

The paper presents a multi-omics digital research object for studying sleep regulation in mice, integrating diverse datasets and analytics to enhance data reusability and reproducibility.

This study shows that CIRBP modulates clock gene expression and REM sleep recovery after sleep deprivation in mice.

This study examines how disrupting the Hcrtr1 gene in noradrenergic neurons affects theta and gamma oscillations in different arousal contexts, revealing context-dependent changes in brain activity.