Cesare Gargioli

This study identifies SAA1-TLR4 signaling as a tumor-derived pathway driving muscle wasting in pancreatic cancer, showing that targeting this pathway can preserve muscle mass and improve survival without affecting tumor growth.

Myo-REG integrates and curates molecular interactions and signaling pathways involved in muscle regeneration, providing a web portal for exploring cell-cell and intracellular interactions.

This study uses single-cell mass cytometry to analyze skeletal muscle cell dynamics during regeneration and ageing, revealing population heterogeneity and responses to perturbations.

This study shows that NOTCH signaling inhibits adipogenesis in wild-type FAPs but not in mdx FAPs, with TNF-α restoring NOTCH sensitivity in mdx FAPs.