P. Lorenzo Bozzelli

The paper shows that combining CSF1R inhibition with GENUS stimulation improves cognitive function in Alzheimer's mice by restoring neural circuitry and gene expression.

The paper identifies that DNA double strand breaks in neurons activate immune pathways, leading to microglia activation in neurodegeneration.

This study shows that APOE4 in microglia causes lipid accumulation, impairing their ability to monitor neuronal activity and leading to disrupted neuronal network function.

This study shows that parvalbumin basket cells are less active during SWRs in a mouse AD model, contributing to memory impairment.

This study shows venlafaxine reduces PNN integrity and increases gamma power via MMP-9 in mice, linking it to antidepressant effects.

This study shows that disrupting perineuronal nets increases sharp wave ripple frequency in the hippocampus of mice.