Author

Tohru Kiyono

National Cancer Center Exploratory Oncology Research & Clinical Trial CenterORCID 0000-0003-1769-403XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Genetics· 2 Cancer Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 4 Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Assay:spatial transcriptomics· 2 Research Focus:cancer & tumor microenvironment· 1 Approach:deep learning· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Ali MortazaviiD· 2 shared Jonathan Chau· 2 shared Katherine WilliamsiD· 2 shared Kyoko YokomoriiD· 2 shared Nam Viet NguyeniD· 2 shared Rabi TawiliD· 2 shared Xiangduo KongiD· 2 shared Altay Bayrakci· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersGenetics

Ali MortazaviORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Integrating spatial and single-cell multi-omics analysis of induced pluripotent stem cell-derived cervical adenocarcinoma model

Saki Kamata, Ayumi Taguchi, Hitoshi Iuchi, Yuji Ikeda, Rie Maruyama, Yoko Nakanishi, Toshihiro Sugi, Yuki Okuma, Osamu Kobayashi, Naoko Tomita, Daisuke Yoshimoto, Lifang Wang, Nozomi Moritsugu, Chitose Takahashi, Michihira Tagami, , Kei Kawana

The paper establishes an HPV18-associated cervical adenocarcinoma model using iRCs and integrates spatial transcriptomics with single-cell multi-omics to identify Gland_A as a key component with specific molecular features.

bioRxiv · May 6, 2026 · PreprintCancer Biology

Construction of a novel 3D urinary bladder mucosa model and its application in toxicity assessment of arsenicals

Runjie Guo, Min Gi, Tohru Kiyono, Arpamas Vachiraarunwong, Shugo Suzuki, Masaki Fujioka, Guiyu Qiu, Kwanchanok Praseatsook, Yurina Kawamura, Anna Kakehashi, Ikue Noura, Xiao‐Li Xie, Hideki Wanibuchi

This paper constructs a 3D urinary bladder mucosa model and uses it to assess the toxicity of arsenicals, showing dose-dependent cytotoxic effects and potential carcinogenic mechanisms.

Toxics · Sep 29, 2025Peer-reviewedPharmacology & Toxicology

Engineered SMCHD1 and D4Z4 mutations reveal roles of D4Z4 heterochromatin disruption and feedforward DUX4 network activation in FSHD

Xiangduo Kong, Nam Viet Nguyen, Yumeng Li, Jasmine Sakr, Katherine Williams, Sheila Sharifi, Jonathan Chau, Altay Bayrakci, Seiya Mizuno, Satoru Takahashi, Tohru Kiyono, Rabi Tawil, Ali Mortazavi, Kyoko Yokomori

The paper uses engineered human myoblasts to show that D4Z4 heterochromatin disruption and DUX4 network activation are key in FSHD.

bioRxiv · Oct 14, 2022 · PreprintGenetics

Relationship of DUX4 and target gene expression in FSHD myocytes

Jonathan Chau, Xiangduo Kong, Nam Viet Nguyen, Katherine Williams, Miya Ball, Rabi Tawil, Tohru Kiyono, Ali Mortazavi, Kyoko Yokomori

The paper uses RNA FISH to study DUX4 and its target gene expression dynamics in FSHD patient myocytes, revealing a unique expression pattern and self-sustaining target gene network.

Human Mutation · Jan 27, 2021Peer-reviewedGenetics