Satoru Takahashi

Continuous Large Maf Activity Maintains Fast Myofiber Identity and Multicellular Homeostasis in Adult Skeletal Muscle

Expression status transition of NOTCH1 accompanies chromatin remodeling in human early retinal progenitor cells

The paper examines NOTCH1 expression changes in human retinal progenitor cells and links them to chromatin remodeling using single-cell RNA-seq and ATAC-seq data.

Visualization of neuronal morphology of the suprachiasmatic nucleus vasopressin neurons by Cre/FLPe-based genetic two-step sparse labelling - GT-SPARCL

The paper introduces GT-SPARCL, a genetic method for low-density neuronal labeling in mice, and applies it to reveal morphological subtypes of AVP neurons in the SCN.

TSUMUGI: a platform for phenotype-driven gene network identification from comprehensive knockout mouse phenotyping data

TSUMUGI identifies gene networks driven by phenotypes using IMPC knockout mouse data to facilitate hypothesis generation for complex phenotypes.

Early development of male germ cell clones shapes their reproductive success

The paper traces individual PGC clones in mice to show early stochastic bottlenecks shape clonal contributions and reproductive success.

Muc6-expressing gastric isthmus progenitors contribute to regeneration and metaplasia supported by myeloid-mesenchymal interactions

This study identifies Muc6-expressing isthmus progenitors as key contributors to gastric regeneration and metaplasia through myeloid-mesenchymal interactions.

Ablation of Max expression induces meiotic onset in sexually undifferentiated germ cells

This study shows that Max gene disruption in germ cells leads to meiotic onset but results in apoptosis due to stalled meiotic progression.

Engineered SMCHD1 and D4Z4 mutations reveal roles of D4Z4 heterochromatin disruption and feedforward DUX4 network activation in FSHD

The paper uses engineered human myoblasts to show that D4Z4 heterochromatin disruption and DUX4 network activation are key in FSHD.

Coordination chemogenetics for activation of GPCR-type glutamate receptors in brain tissue

This paper develops a chemogenetic method to selectively activate mGlu1 receptors in brain tissue using a palladium complex and a mutant receptor, demonstrating its role in synaptic plasticity.

Multiplex genotyping method to validate the multiallelic genome editing outcomes using machine learning-assisted long-read sequencing

This paper introduces DAJIN, a machine learning-assisted long-read sequencing method for comprehensive multiplex genotyping of genome editing outcomes, including intended and unintended mutations.

Unraveling the roles of Mast4 in amelogenesis via regulating DLX3 and stem cell maintenance of mouse incisors

This study identifies MAST4's role in regulating DLX3 and stem cell maintenance in mouse incisor development, leading to Amelogenesis Imperfecta.

EXOC1 regulates cell morphology of spermatogonia and spermatocytes in mice

This study identifies EXOC1's role in regulating pseudopod formation in spermatogonia and syncytium formation in spermatocytes in mice, highlighting its interaction with Rac1 and SNAP23/STX2.

Lin28a/let-7 Pathway Modulates the Hox Code via Polycomb Regulation during Axial Patterning in Vertebrates

This study shows the Lin28a/let-7 pathway regulates Hox gene expression during axial patterning by modulating Polycomb complex occupancy in vertebrates.

Re-Evaluating One-step Generation of Mice Carrying Conditional Alleles by CRISPR-Cas9-Mediated Genome Editing Technology

The paper re-evaluates the efficiency of a CRISPR-Cas9 method for generating conditional knockout alleles in mice, finding very low success rates and high rates of undesired alleles.