Kyle A. Cottrell

This study shows that ZYS-1 is not a selective inhibitor of ADAR1, as it does not reduce A-to-I editing or affect ADAR1-dependent cell line survival.

This study shows ADAR1 protects TNBC cells from ferroptosis by regulating lipid composition, and identifies cobimetinib as a potential therapeutic agent when combined with ADAR1 loss.

This study shows that an shRNA targeting DDX54 can activate PKR through a dsRNA-mediated mechanism, highlighting the need for careful validation of gene function.

The paper shows that loss of DHX9 and ADAR1 in breast cancer cells activates dsRNA sensing pathways, leading to a viral mimicry phenotype.

The paper shows that a short translational ramp in mRNA's first 5 codons significantly affects protein synthesis efficiency, independent of tRNA abundance or initiation efficiency.