Sergej Djuranović

RAPPL-Seq enables rapid, high-sensitivity ribosome profiling of scarce samples by improving RPF recovery efficiency and reducing processing time.

The paper demonstrates that antisense oligonucleotides (ASOs) can upregulate gene expression by stabilizing mRNA through targeting destabilizing elements like PREs, with therapeutic implications for haploinsufficiency disorders.

This study shows that ZCRB1 is essential for U12 splicing, ciliogenesis, and WNT signaling, with loss-of-function effects observed in human cells and zebrafish.

This study shows that mitochondrial ETF insufficiency promotes cancer growth by reprogramming bioenergetics and signaling pathways in neoplastic cells.

This paper introduces RAPPL, a rapid, simple, and cost-effective method for isolating ribosomes and translational machinery, demonstrating its utility in functional and structural studies across various species and sample types.

The paper identifies U-rich elements in 3' UTRs as drivers of cryptic splicing in MPRA, showing they affect splice site choice and expression levels.

The paper screens 5'UTR mutations in neurodevelopmental disorder genes to identify functional variants impacting translation and protein production, finding some mutations affect known syndromic autism genes in neurons.

This study shows that RACK1 in Plasmodium falciparum is bound to ribosomes and polysomes, despite structural conservation across species.

This study creates hypomorphic mutants using polyA tracks and CRISPR/Cas9, showing programmable reductions in mRNA and protein levels for specific genes.

The paper shows that a short translational ramp in mRNA's first 5 codons significantly affects protein synthesis efficiency, independent of tRNA abundance or initiation efficiency.