Samuel R Witus

The paper shows proteasomes degrade repressive transcription factors, freeing chromatin for activator binding and enabling gene expression and cell fate decisions.

This study identifies purine nucleotides as molecular glues that regulate purine biosynthesis by tethering PPAT to NUDT5, and shows how thiopurine drugs function as metabolic glues with enhanced potency.

The paper shows that centromeric DNA sequences enhance force transmission through the inner kinetochore via the Okp1/Ame1 complex.

This study determines the structure of the human E3 ligase SIFI, revealing its mechanism for ubiquitinating multiple substrates to silence the integrated stress response.