Author
University of California, BerkeleyORCID 0000-0003-3909-9573Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
Recent·Most cited
Samuel R Witus, Megan M. Kober, Heegwang Roh…·Michael Rapé
This study identifies purine nucleotides as molecular glues that regulate purine biosynthesis by tethering PPAT to NUDT5, and shows how thiopurine drugs function as metabolic glues with enhanced potency.
Megan M. Kober, Xinyi Yang, Bradley A. Webb, Denis V. Titov
The paper shows F26BP regulates glycolytic rate independently of energy state, distinguishing it from other regulators, and identifies downstream intermediates that control F26BP levels.
Alex E. Ekvik, Megan M. Kober, Denis V. Titov
The paper develops ATPGobble, a genetically encoded tool to manipulate ATP/ADP ratios in human cells, showing it increases energy demand and activates AMPK.