Dual Modes of Gene Regulation by CDK12
Yubao Wang, Apoorva Baluapuri, Cherubin Manokaran, Jing Ni, Tao Jiang, Roel C. Janssens, Jurgen A. F. Marteijn, Karen Adelman, Jean J. Zhao, Thomas M. Roberts
This study shows CDK12 inhibition both downregulates and upregulates gene expression, with implications for cancer therapy.
bioRxiv · Sep 22, 2025 · PreprintCancer Biology