William E. Kraus

In 174 sedentary adults, resistance exercise changed more muscle molecular features than endurance exercise across omes and time points; network analysis nominates MEF2A and NFIC as regulatory hubs.

The paper presents initial findings from the MoTrPAC consortium, showing that acute and chronic exercise induce distinct physiological and molecular responses, with chronic training improving key health metrics.

This study identifies shared and sex-specific molecular responses to endurance training in skeletal muscle using multi-omics data from rats.

This study examines how aerobic exercise affects small RNA expression in skeletal muscle and plasma, linking changes to improved insulin sensitivity.

This study identifies tissue-specific lncRNA responses to endurance exercise in rats, revealing sex differences and potential therapeutic implications.

The paper identifies tissue-specific transcriptional regulatory programs in rats undergoing endurance exercise training by integrating chromatin accessibility, DNA methylation, and gene expression data.

This paper develops a network-based atlas of human skeletal muscle aging using transcriptomic data from 1,675 biopsies and multiple single-cell technologies, revealing gene modules and interactions associated with aging and load status.

The paper identifies molecular predictors of muscular strength preservation during calorie restriction-induced weight loss using transcriptomic analysis of skeletal muscle samples.

The paper presents a genomic data resource from a caloric restriction trial, including SNP genotypes and multi-omic longitudinal data from multiple tissues.

This study examines how endurance exercise training affects rat subcutaneous white adipose tissue, revealing sex-specific molecular responses and differences in adiposity and metabolism.

This study shows that culturing blood samples and measuring circadian gene expression correlates more closely with in vivo samples than non-circadian genes, validating a minimally invasive method for circadian analysis.

This study profiles multi-omic changes in multiple tissues of rats during endurance exercise training, identifying molecular adaptations and sex-specific responses across time.

This study analyzes DNA methylation changes in humans undergoing calorie restriction, finding CR-induced DNAm changes opposite BMI and smoking associations and aligned with aging-related CpG sites.

The paper develops a DNA methylation-based blood test, DunedinPoAm, to quantify individual differences in the pace of biological aging and validates its association with aging-related outcomes across multiple studies.