Author

Maria Gaughan

University of Massachusetts Chan Medical School

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

David A. GuertiniD· 2 shared Ekaterina D. KorobkinaiD· 2 shared Flaviane de Fátima SilvaiD· 2 shared Huawei LiiD· 2 shared Qingbo CheniD· 2 shared Abigail O. SmithiD· 1 shared Alan C. MulleniD· 1 shared Alexander R. BoucheriD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersPhysiology

David A. GuertinORCID

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2 papers

Recent·Most cited

UCP1 Mitigates Hepatic Steatosis and Fibrosis Independent of Cold Exposure

John D. Haley, Johnny Le, Rui Li, Ekaterina D. Korobkina, Flaviane de Fátima Silva, Maria Gaughan, Timothy P. Fitzgibbons, Nuria Martinez Gutierrez, Qingbo Chen, Shelagh M. Fluharty, Huawei Li, Caroline A. Lewis, John E. Harris, Lihua Julie Zhu, Alan C. Mullen, , David A. Guertin

This study shows diet-induced thermogenesis reduces adiposity and protects against liver disease in male mice, with UCP1 playing a key role in BAT and non-adipocyte cells.

bioRxiv · Aug 5, 2025 · PreprintPhysiology

Rag GTPases Suppress Renal Cystic Disease by Inhibiting TFEB Independently of mTORC1

Flaviane de Fátima Silva, Alexander R. Boucher, Huawei Li, Qingbo Chen, Maria Gaughan, Ekaterina D. Korobkina, Marie Sophie Isidor, Abigail O. Smith, Kuang Shen, Derek B. Allison, Pamela Vivian Tran, Gregory J. Pazour, David A. Guertin

This study shows that Rag GTPases suppress renal cystic disease by inhibiting TFEB, independent of mTORC1, and identifies nuclear TFEB as a better biomarker than mTORC1 activation.

bioRxiv · Jul 24, 2025 · PreprintCell Biology