Aviva M. Tolkovsky

The paper shows that microglia phagocytosing neurons with tau aggregates become hypofunctional and release tau seeds, contributing to tauopathy progression.

This study tracks tau fibrillogenesis and microglial phagocytosis of neurons in a living tauopathy model, showing that microglia engulf tangle-bearing neurons and that TSPO ligands can reduce this process.