Bin Ji

Non-invasive imaging of tau-targeted probe uptake by whole brain multi-spectral optoacoustic tomography

This paper demonstrates non-invasive whole brain imaging of tau deposits using vMSOT and PBB5 probe in P301L mice, showing specific binding and retention in tau-laden regions.

Tracking tau fibrillogenesis and consequent primary phagocytosis of neurons mediated by microglia in a living tauopathy model

This study tracks tau fibrillogenesis and microglial phagocytosis of neurons in a living tauopathy model, showing that microglia engulf tangle-bearing neurons and that TSPO ligands can reduce this process.

Deschloroclozapine, a potent and selective chemogenetic actuator enables rapid neuronal and behavioral modulations in mice and monkeys

This paper introduces deschloroclozapine (DCZ), a potent and selective DREADD agonist that rapidly modulates neuronal activity and behavior in mice and monkeys.