Author

Hiroyasu Akatsu

Fukushimura HospitalORCID 0000-0002-0089-6033Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetic & Genomic Medicine· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Research Focus:cell-cell communication· 1 Approach:experimental assay· 1 Assay:GWAS summary statistics· 1 Organism:human· 1 Assay:imaging· 1 Organism:mouse· 1 Research Focus:polygenic risk· 1 Approach:statistical model· 1

Frequent Co-Authors

Adam FleisheriD· 1 shared Ai IshikawaiD· 1 shared Akihiro NakayaiD· 1 shared Akinori MiyashitaiD· 1 shared Akiyoshi KakitaiD· 1 shared Angela OliveriD· 1 shared Anna M. BarroniD· 1 shared Arthur W. TogaiD· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperGenetic & Genomic Medicine

Adam FleisherORCID

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2 papers

Recent·Most cited

Polygenic effects on the risk of Alzheimer's disease in the Japanese population

Masataka Kikuchi, Akinori Miyashita, Norikazu Hara, Kensaku Kasuga, Yuko Saito, Shigeo Murayama, Akiyoshi Kakita, Hiroyasu Akatsu, Kouichi Ozaki, Shumpei Niida, Ryozo Kuwano, Takeshi Iwatsubo, Akihiro Nakaya, Takeshi Ikeuchi, the Alzheimer’s Disease Neuroimaging Initiative, , Gary R. Conrad

This paper evaluates the polygenic risk score for Alzheimer's disease in Japanese individuals, showing its utility despite genetic differences from European populations.

Alzheimer s Research & Therapy · Feb 27, 2024Peer-reviewedGenetic & Genomic Medicine

Tracking tau fibrillogenesis and consequent primary phagocytosis of neurons mediated by microglia in a living tauopathy model

Hiroyuki Takuwa, Asumi Orihara, Yuhei Takado, Takuya Urushihata, Masafumi Shimojo, Ai Ishikawa, Manami Takahashi, Anna M. Barron, Maiko Ono, Jun Maeda, Kazuto Masamoto, Hiroyasu Akatsu, Aviva M. Tolkovsky, Bin Ji, 裕冨田, , Makoto Higuchi

This study tracks tau fibrillogenesis and microglial phagocytosis of neurons in a living tauopathy model, showing that microglia engulf tangle-bearing neurons and that TSPO ligands can reduce this process.

bioRxiv · Nov 4, 2020 · PreprintNeuroscience