Makoto Higuchi

This study longitudinally assesses DREADD expression and efficacy in macaque monkeys using PET imaging and functional studies, showing peak expression at 60 days and sustained effects for two years.

This paper presents an fMRI dataset capturing color qualia similarity judgments with and without verbal reports from 35 participants.

This study identifies TRPC6 as a critical mechanosensitive channel required for ultrasound-induced neuromodulation in mammalian neurons.

The paper describes the development of triple MAPT mutation knock-in mice that exhibit early tau pathology and behavioral abnormalities, useful for studying frontotemporal dementia and related tauopathies.

This paper investigates the metabolic stability and deposition of A{beta}3pE-42, a target of the Alzheimer's antibody donanemab, showing it is more stable than other A{beta}X-42 species and accumulates with age.

This paper introduces SMP, an unsupervised algorithm for decomposing primate behavior into motion motifs, outperforming existing methods and visualizing neural manipulation effects.

This study identifies distinct OFC-subcortical pathways in macaques that support experience-based and inference-based value updating during adaptive decision-making.

The paper validates and optimizes the PSAM/PSEM chemogenetic system in nonhuman primates using multimodal imaging techniques to determine optimal agonist, dose, and timing for neuronal manipulation.

This study shows that 5-HT1A and 5-HT1B receptor blockade separately affects motivation by altering sensitivity to cost and reward in monkeys.

This study disrupts the connection between the orbitofrontal cortex and rostromedial caudate nucleus in macaques using chemogenetics, showing it impairs reward-based motivational control of goal-directed actions.

The paper introduces a method to visualize neurotransmission at synapses using split protein sensors, demonstrating functionality in cultured cells, worms, and mouse brains.

This paper demonstrates non-invasive whole brain imaging of tau deposits using vMSOT and PBB5 probe in P301L mice, showing specific binding and retention in tau-laden regions.

The paper identifies a whole-brain neural network predicting superiority illusion and striatal dopamine levels using resting-state fMRI data.

The paper examines how resting-state functional connectivity relates to individual differences in positive memory recollection, identifying a frontotemporal network associated with positive memory performance.

This study uses DREADD technology in common marmosets to show that chemogenetic activation of nigrostriatal dopamine neurons induces contralateral rotation behavior.

The paper investigates the relationship between behavioral inhibition system scores and 5-HT2A receptor availability in the anterior cingulate cortex, identifying a functional connectivity network involving the left middle frontal gyrus.

This study investigates how D1-like and D2-like dopamine receptors influence cost/benefit evaluation and motivation in monkeys using pharmacological manipulation and PET imaging.

This study uses chemogenetic methods to selectively silence prefronto-subcortical pathways in monkeys, revealing distinct roles in working memory and decision-making.

This paper develops [11C]MTP38 as a PET ligand for PDE7 and demonstrates its preclinical success in imaging PDE7 in the brain.

This study tracks tau fibrillogenesis and microglial phagocytosis of neurons in a living tauopathy model, showing that microglia engulf tangle-bearing neurons and that TSPO ligands can reduce this process.

This paper introduces deschloroclozapine (DCZ), a potent and selective DREADD agonist that rapidly modulates neuronal activity and behavior in mice and monkeys.

This paper develops a PET-based method using ecDHFR and TMP analogs to image neuronal networks in mammalian brains, enabling visualization of neuronal activity and protein dynamics.