Pharmacological potentiation of Nav1.1 channels in interneurons mitigates tau depositions and neuronal death in a mouse model of neurodegenerative dementias
Kazuaki Sampei, Junya Hirokawa, Takehiro Kudo…·Masafumi Shimojo
Author
National Institutes for Quantum Science and TechnologyORCID 0000-0001-7484-8424Unclaimed ORCID profile · follow to get notified of new preprints
6 papers
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Kazuaki Sampei, Junya Hirokawa, Takehiro Kudo…·Masafumi Shimojo
Takahiro Hirao, Mitsuhiro Miyamae, Daisuke Matsuyoshi…·Makiko Yamada
This paper presents an fMRI dataset capturing color qualia similarity judgments with and without verbal reports from 35 participants.
Hironobu Endo, Maiko Ono, Yuhei Takado…·Makoto Higuchi
This study develops a PET ligand to visualize α-synuclein pathologies in Parkinson's and DLB patients, showing increased signals in affected brain regions.
Yuhei Takado, Hiroyuki Takuwa, Kazuaki Sampei…·Makoto Higuchi
The paper shows that MRS-measured Glutamate and GABA levels in awake mice correlate with excitatory and inhibitory neural activities during stimulation and in a Dravet syndrome model.
Hiroyuki Takuwa, Asumi Orihara, Yuhei Takado…·Makoto Higuchi
This study tracks tau fibrillogenesis and microglial phagocytosis of neurons in a living tauopathy model, showing that microglia engulf tangle-bearing neurons and that TSPO ligands can reduce this process.
Masafumi Shimojo, Maiko Ono, Hiroyuki Takuwa…·Makoto Higuchi
This paper develops a PET-based method using ecDHFR and TMP analogs to image neuronal networks in mammalian brains, enabling visualization of neuronal activity and protein dynamics.