Ryan B. MacDonald

This study improves killifish retinal transcriptome annotation using long-read sequencing, identifying thousands of previously unannotated transcripts and enhancing gene naming accuracy.

The paper identifies a CYP26A1/CRYAA progenitor-glial domain in the human retina that marks the presumptive macula and links it to regional gliogenic maturation and specialized Muller glial populations.

The paper shows that Muller glia regulate retinoic acid (RA) levels in zebrafish retina to control cone OS length and functional specialisation in the acute zone.

This study shows that Mmp2 and Mmp9 are essential for Muller glia morphogenesis and neuronal maintenance in the zebrafish retina.

This study shows that turquoise killifish develop AMD-like features with age, making them a suitable model for studying age-related macular degeneration.

This study uses bulk and single-cell RNA-seq to analyze age-related transcriptome changes in the African turquoise killifish retina, identifying oxidative stress, gliosis, and inflammageing, and highlighting dysregulation of retinal disease genes.

IBEX imaging enables simultaneous identification of all cell types in the vertebrate retina across multiple species.

This study shows that C9ORF72 deficiency in zebrafish causes retinal degeneration, including reduced thickness, gliosis, and neuronal loss, but not spinal cord pathology.

GliaMorph quantifies Müller glial cell morphology across developmental and disease states, revealing structural changes and subcellular features in zebrafish and mouse models.

The paper identifies distinct cell type-specific functions of two overlapping PAX6 retinal enhancers using live imaging and single-cell RNA sequencing in zebrafish.

The paper shows that aged gliotic Müller glia in zebrafish retain regenerative potential and can be stimulated to repair damaged neurons despite age-related neurodegeneration.

This study shows glucose exposure harms the neurovascular unit and behavior in zebrafish, but sodium nitroprusside reverses these effects.

The paper investigates the additive effect of genetic risk variants for Parkinson's disease and finds an unexpected rescue effect on neuronal function and survival in zebrafish with combined GCase and ASM deficiency.

The paper describes the discovery of transient NO-containing spherical structures in zebrafish cerebral endothelial cells during development, showing their dependence on Notch signaling.