Claudio Mussolino

The paper introduces a therapeutic strategy called castling to correct gene-expression imbalances by rewiring miRNA regulation using the TRIPLE genome-editing technology.

This study shows CD20 phosphorylation by PKCδ links it to the RhoA/Rock1 pathway via 14-3-3 and GEF-H1, regulating MT stability and actomyosin contractility in B cells.

The paper identifies a DNA sequence between CRX and NRL that regulates RHODOPSIN expression levels through its interaction with transcription factors.

This paper demonstrates efficient gene editing in FA mouse models using TALENs and a donor template at a safe harbor locus, achieving phenotypic correction of FA cells.