This study identifies APOE4/4-driven dysfunctional microglial states in Alzheimer's disease through multiomic analysis, revealing shifts toward terminal states with metabolic disruption and inflammatory signaling.

bioRxiv · Jun 19, 2026 · PreprintImmunology

Single-cell Spatial Proteomic Imaging for Human Neuropathology

Kausalia Vijayaragavan, Bryan J. Cannon, Dmitry Tebaykin, Marc MB Bosse, Alex Baranski, John Paul Oliveria, Syed Abbas Bukhari, Dunja Mrdjen, M. Ryan Corces, Erin McCaffrey, Noah F. Greenwald, Yaron M. Sigal, Diana M. Marquez, Zumana Khair, Trevor Bruce, , Sean C. Bendall

This study uses spatial proteomics to analyze human brain tissues and identifies proteopathies and cell interactions in Alzheimer's disease.

Acta Neuropathologica Communications · Nov 4, 2022Peer-reviewedSystems Biology

Single-synapse analyses of Alzheimers disease implicate pathologic tau, DJ1, CD47, and ApoE

Thanaphong Phongpreecha, Chandresh R. Gajera, Candace C. Liu, Kausalia Vijayaragavan, Alan Lee Chang, Martin Becker, Ramin Fallahzadeh, Rosemary Fernandez, Nadia O. Postupna, Emily Sherfield, Dmitry Tebaykin, Caitlin S. Latimer, Carol A. Shively, Thomas C. Register, Suzanne Craft, , Thomas Jude Montine

The paper analyzes synaptic molecular changes in Alzheimer's disease and related conditions using mass cytometry and imaging, identifying disease-specific molecular differences.

Science Advances · Dec 15, 2021Peer-reviewedNeuroscience