Pranav P. Mathkar

A region-delineated snRNA-seq atlas of mouse spinal cord across lifespan resolves the interaction of normative aging programs with SOD1-G93A ALS

This study creates a lifespan snRNA-seq atlas of mouse spinal cord, revealing how aging and SOD1-G93A ALS interact regionally and cell-type specifically.

Single-cell Atlas Unveils Cellular Heterogeneity and Novel Markers in Human Neonatal and Adult Intervertebral Discs

The paper generates and compares single-cell atlases of human neonatal and adult intervertebral discs to identify cellular heterogeneity, sub-populations, and developmental trajectories.

Single-cell RNA-seq analysis of human iPSC-derived motor neurons resolves early and predictive ALS signatures

The paper uses single-cell RNA-seq to identify early ALS signatures in iPSC-derived motor neurons across multiple models and platforms.