Author

Shaocheng Wu

BC Cancer AgencyORCID 0000-0002-1663-7132Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 5 Approach:statistical model· 5 Research Focus:clustering· 4 Assay:spatial transcriptomics· 4 Research Focus:cell type annotation· 3 Research Focus:cell-cell communication· 3 Research Focus:differential expression· 3 Research Focus:gene regulatory network inference· 3

Frequent Co-Authors

Andrew J. L. RothiD· 4 shared Christian SteidliD· 4 shared Tomohiro AokiiD· 4 shared Adèle TeleniusiD· 3 shared Andrew Lytle· 3 shared Andrew P. WengiD· 3 shared Clémentine SarkozyiD· 3 shared David W. ScottiD· 3 shared

Activity by Year

2022-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersCancer Biology

Andrew J. L. RothORCID

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5 papers

Recent·Most cited

Developmental origins of thymic B-cell lymphomas

Shinya Rai, Yifan Yin, Manabu Fujisawa, Makoto Kishida, Michael Yu Li, Jeffrey Niu, Aixiang Jiang, Laura K. Hilton, Amos Fong, Gerben Duns, Adèle Telenius, Barbara Meissner, Merrill Boyle, Hisae Nakamura, Alexandra Roos, , Christian Steidl

This study identifies a thymus-specific B-cell differentiation program linked to thymic B-cell lymphomagenesis through single-cell multiomics and spatial profiling.

bioRxiv · Oct 20, 2026 · PreprintCancer Biology

Resolving the immune response across clonal cancer evolution in situ with Atera whole transcriptome profiling

Shaocheng Wu, Mohita Mahajan, Maarten van der Linde, Chunfang Zhu, Robert B. West, David G.P. van IJzendoorn, Magdalena Matusiak

This study evaluates Atera, a spatial transcriptomics platform, showing its ability to resolve clonal cancer evolution and immune response in situ using DCIS samples.

bioRxiv · Aug 21, 2026 · PreprintBioinformatics

Single-cell spatial multi-omic characterization of the tumour microenvironment in transformed follicular lymphoma

Shaocheng Wu, Eric Lee, Anne-Sophie Fratzscher, Andrew Lytle, Spencer D. Martin, Tina Hsu, Adèle Telenius, Yifan Yin, Amos Fong, Shinya Rai, Manuba Fujisawa, Honor Cheung, Samuel A. J. R. Aparicio, David D. Huntsman, Tomohiro Aoki, , Andrew J. L. Roth

The paper uses multi-omic single-cell spatial techniques to study FL transformation, finding spatial shifts in B-cell neighborhoods and immunomodulatory interactions linked to disease progression.

bioRxiv · Aug 18, 2026 · PreprintBioinformatics

Multidimensional characterization of cellular ecosystems in Hodgkin lymphoma

Tomohiro Aoki, Gerben Duns, Shinya Rai, Aixiang Jiang, Andrew Lytle, Yifan Yin, Makoto Kishida, Michael Yu Li, Denise Smorra, Laura K. Hilton, Stefan Alig, Mohammad Shahrokh Esfahani, Clémentine Sarkozy, Stacy S. Hung, Katy Milne, , Christian Steidl

This study identifies four molecular subtypes of Hodgkin lymphoma using multimodal data, revealing distinct clinical features and immune ecosystem dynamics.

bioRxiv · Mar 18, 2025 · PreprintCancer Biology

Integrated single cell analysis reveals co-evolution of malignant B cells and the tumor microenvironment in transformed follicular lymphoma

Clémentine Sarkozy, Shaocheng Wu, Katsuyoshi Takata, Tomohiro Aoki, Susana Ben Neriah, Katy Milne, Talia Goodyear, Celia Strong, Tashi Rastogi, Daniel Lai, Laurie Helen Sehn, Pedro Farinha, Brad H. Nelson, Andrew P. Weng, David W. Scott, , Andrew J. L. Roth

The paper uses single-cell sequencing to study the evolution of follicular lymphoma and its microenvironment during transformation, finding gene programs and TME changes associated with progression.

bioRxiv · Nov 17, 2022 · PreprintBioinformatics