ImmunologyOncogenePeer-reviewed
Methylmalonic acid induces metabolic abnormalities and exhaustion in CD8+ T cells to suppress anti-tumor immunity
Joanne D. Tejero, Rebecca S. Hesterberg, Stanislav Drápela…·Ana P. Gomes
This study shows that methylmalonic acid impairs CD8+ T cell function and promotes tumor growth by inducing metabolic dysfunction and exhaustion.
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