Author

Hossein Kashfi

Moffitt Cancer Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Organism:human· 1 Organism:mouse· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Ana P. GomesiD· 2 shared Didem IlteriD· 2 shared Elsa Renee FloresiD· 2 shared Felicia Lazure· 2 shared John H. LockhartiD· 2 shared Nadir Sarigul· 2 shared Stanislav DrápelaiD· 2 shared Alex M. JaegeriD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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2 shared papersCancer Biology

Ana P. GomesORCID

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2 papers

Recent·Most cited

Quinolinic acid phosphoribosyl transferase moonlights as an apoptosis regulator to empower lung cancer progression

Hossein Kashfi, Didem Ilter, Angelo A. Nicolaci, John H. Lockhart, Stanislav Drápela, Felicia Lazure, Devesh Raizada, Nadir Sarigul, Julia Spegel, Nathan P. Ward, Tumpa Dutta, Stephen J. Gardell, Jennifer M. Binning, Elsa Renee Flores, Gina M. DeNicola, Ana P. Gomes

This study identifies QPRT as a non-canonical apoptosis regulator in NSCLC that suppresses caspase-3 activation, independent of its role in NAD biosynthesis, suggesting it as a therapeutic target.

bioRxiv · Apr 3, 2026 · PreprintCancer Biology

Aging directs the differential evolution of KRAS-driven lung adenocarcinoma

Felicia Lazure, Stanislav Drápela, Xiaoxian Liu, John H. Lockhart, Hossein Kashfi, Nadir Sarigul, Didem Ilter, Elsa Renee Flores, Xuefeng Wang, Inna Smalley, Alex M. Jaeger, Xiaoqing Yu, Ana P. Gomes

This study uses single-cell RNA-sequencing to show that aging promotes KRAS-driven lung adenocarcinoma evolution toward a stem-like state through age-related changes in the tumor microenvironment.

bioRxiv · Jan 20, 2025 · PreprintCancer Biology