Marcel Deponte

This study shows that PfGrx rapidly reduces glutathione polysulfides, generating hydrogen sulfide and glutathionylated enzyme, with rate constants comparable to glutathione disulfide reduction.

This study identifies HS- as a universal reducing agent for Prx6-type peroxiredoxins, showing rapid reactivity with oxidized PfPrx6 and human PrxVI.

The paper shows that eukaryotic Prx1/AhpC-type peroxiredoxins form heterooligomers, which modulate their structure and stability, challenging the previous belief in homooligomerization.

This study identifies Tsa1 as the primary peroxide scavenger in yeast and shows it can generate GSSG under H2O2 conditions.

The paper tests CRISPR-Cas9 and glmS ribozyme systems for gene disruption and knock-down in Leishmania tarentolae, finding success with CRISPR-Cas9 and limited effectiveness with glmS.