Author

Zhiguo Zheng

Chinese Academy of SciencesORCID 0000-0003-2142-8367Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:proteomics· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Research Focus:database / resource· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:perturbation response prediction· 1

Frequent Co-Authors

Cong LuiD· 2 shared Fangfei ZhangiD· 2 shared Jiang ZhuiD· 2 shared Nan XiangiD· 2 shared Qi‐Jun WuiD· 2 shared Tiannan GuoiD· 2 shared Tong LiuiD· 2 shared Wei LiuiD· 2 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersBioinformatics

Cong LuORCID

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3 papers

Recent·Most cited

Droplet-based organoid screens enable high-throughput identification of cancer vulnerabilities

Yanan Xia, Yuting Sun, Yimin Wang, Mingyang Zhang, Guangyue Li, Xinyi Dai, Xinyue Li, Can Hu, Zhiyuan Xu, Li Yuan, Zhiguo Zheng, Xiangdong Cheng, Xin Jin

This paper introduces a droplet-based organoid culture method for high-throughput screening of cancer vulnerabilities, identifying novel therapeutic targets in stomach cancer.

bioRxiv · Oct 19, 2026 · PreprintCancer Biology

DPHL v2: An updated and comprehensive DIA pan-human assay library for quantifying more than 14,000 proteins.

Zhangzhi Xue, Tiansheng Zhu, Fangfei Zhang, Cheng Zhang, Nan Xiang, Liujia Qian, Xiao Yi, Yaoting Sun, Wei Liu, Xue Cai, Linyan Wang, Xizhe Dai, Liang Yue, Lu Li, Thang V. Pham, , Tiannan Guo

DPHL v2 improves upon DPHL v1 by including semi-tryptic peptides and protein isoforms, increasing identified and dysregulated proteins in colorectal cancer analysis.

bioRxiv · Jan 7, 2023 · PreprintBioinformatics

Optimization of Spectral Library Size Improves DIA-MS Proteome Coverage

Weigang Ge, Xiao Liang, Fangfei Zhang, Luang Xu, Nan Xiang, Rui Sun, Wei Liu, Zhangzhi Xue, Xiao Yi, Bo Wang, Jiang Zhu, Cong Lu, Xiaolu Zhan, Lirong Chen, Yan Wu, , Tiannan Guo

This paper presents a computational strategy to optimize spectral library size for DIA-MS data, improving peptide and protein identification rates in colorectal and carcinoma samples.

bioRxiv · Nov 24, 2020 · PreprintBioinformatics