Sibylle Mitschka

The paper shows that subcytoplasmic mRNA localization affects protein output by determining mRNA and protein abundance through compartment-specific translation environments.

The paper shows that mRNAs interact with disordered regions of proteins like MYC to control their activity by enabling specific protein complexes formed in translation sites called TIS granules.

The paper annotates 3'UTR cleavage sites in primary human and mouse cells and introduces scUTRquant to quantify 3'UTR isoform expression from scRNA-seq data, revealing widespread 3'UTR length changes across cell types.

This study shows TRIM71 is essential for germ cell development in mice and links TRIM71 variants to human male infertility.

This study identifies two independent mechanisms by which TRIM71 inhibits let-7 miRNA maturation and activity, impacting developmental and oncogenic processes.