Krupal P. Jethava

Impact Induces Phagocytic Defect in Reactive Microglia

This study uses a TBI-on-a-chip model to show that impact injury reduces microglial phagocytosis and alters lipid metabolism, affecting neuroinflammation and neurodegeneration.

Amyloid beta Induces Lipid Droplet-Mediated Microglial Dysfunction in Alzheimer's Disease

This study identifies lipid droplet formation in microglia as a mechanism linking amyloid-beta exposure to impaired phagocytosis in Alzheimer's disease, with DGAT2 as a therapeutic target.

Monitoring phagocytic uptake of amyloid β into glial cell lysosomes in real time

This study develops a fluorescent Aβ analogue to monitor glial cell phagocytosis of amyloid β in real time, showing microglia uptake exceeds astrocytes.