Author

Yini Li

Johns Hopkins UniversityORCID 0000-0003-2213-0650Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Approach:statistical model· 2 Assay:ChIP-seq· 1

Frequent Co-Authors

Shuying SuniD· 3 shared Jonathan P. LingiD· 2 shared Yingzhi YeiD· 2 shared Alexei M. BygraveiD· 1 shared Ben LangmeadiD· 1 shared Benjamin G. Dubner· 1 shared Chang LiuiD· 1 shared Chuan HeiD· 1 shared

Activity by Year

2022-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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3 shared papersNeuroscience

Shuying SunORCID

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3 papers

Recent·Most cited

NeurosciencebioRxivPreprintSep 30, 2025

LINE1 RNA dysregulation impairs chromatin accessibility in C9ORF72- and TDP-43-linked ALS/FTD

Yini Li, Xiaoyang Dou, Yu Xiao…·Shuying Sun

This study shows that LINE1 RNA dysregulation impairs chromatin accessibility in ALS/FTD, leading to transcriptional changes and neuronal dysfunction.

3 citations

humanDNA methylation

𝕏 PostBluesky

NeurosciencebioRxivPreprintJun 28, 2025

Inhibition of nonsense-mediated decay in TDP-43 deficient neurons reveals novel cryptic exons

Irika R. Sinha, Yingzhi Ye, Yini Li…·Jonathan P. Ling

The paper identifies novel cryptic exons in TDP-43 deficient neurons by inhibiting nonsense-mediated decay, revealing potential therapeutic targets for ALS-FTD.

9 citations

humanbulk RNA-seq

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Molecular BiologyNature CommunicationsPeer-reviewedOct 1, 2022

Cell-specific regulation of gene expression using splicing-dependent frameshifting.

Jonathan P. Ling, Alexei M. Bygrave, Clayton P. Santiago…·Seth Blackshaw

This paper introduces SLED, a splicing-based method to control gene expression in specific cell types, demonstrating its utility in targeting neurons, photoreceptors, and cancer cells.

28 citationstop 5%

mousebulk RNA-seq

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