Marija Krasiļņikova

De novo assembly of the Trypanosoma congolense genome reveals an organisation influenced by antigenic variation but distinct from Trypanosoma brucei

This paper presents a telomere-telomere genome assembly of Trypanosoma congolense, revealing distinct VSG organization and expression mechanisms compared to Trypanosoma brucei.

Trypanosoma congolense Variant Surface Glycoprotein gene expression occurs in the absence of monoallelic transcription control

This study shows that Trypanosoma congolense expresses multiple Variant Surface Glycoprotein genes in single cells, unlike Trypanosoma brucei, which uses monoallelic transcription.

Restricted expression site use and extreme genome diversification drives trypanosome antigenic variation in chronic bovine infections

The paper analyzes antigenic variation in Trypanosoma brucei during chronic bovine infections, revealing enhanced diversity and a reproducible temporal expression hierarchy of VSGs.

vsgseq2: an updated pipeline for analysis of the diversity and abundance of population-wide Trypanosoma brucei VSG expression

vsgseq2 improves the analysis of VSG expression diversity and abundance in Trypanosoma brucei populations using updated bioinformatics tools.

Nuclear DNA replication in Leishmania major relies on a single constitutive origin per chromosome supplemented by thousands of stochastic initiation events

R-loops acted on by RNase H1 are a determinant of chromosome length-associated DNA replication timing and genome stability in Leishmania

This study shows that R-loops and RNase H1 regulate DNA replication timing and genome stability in Leishmania, linking R-loop homeostasis to chromosome size and replication order.

Nanopore sequencing reveals that DNA replication compartmentalisation dictates genome stability and instability in Trypanosoma brucei

This study uses Nanopore sequencing to show that DNA replication compartmentalization in Trypanosoma brucei affects genome stability and instability by influencing VSG gene recombination and chromosome stability.