Catarina A. Marques

This study shows that Trypanosoma congolense expresses multiple Variant Surface Glycoprotein genes in single cells, unlike Trypanosoma brucei, which uses monoallelic transcription.

The paper shows that VSG transcripts play a non-coding role in allelic exclusion in trypanosomes by participating in allelic competition.

This study shows that R-loops and RNase H1 regulate DNA replication timing and genome stability in Leishmania, linking R-loop homeostasis to chromosome size and replication order.

This study uses Nanopore sequencing to show that DNA replication compartmentalization in Trypanosoma brucei affects genome stability and instability by influencing VSG gene recombination and chromosome stability.

The paper analyzes aneuploidy patterns across 866 Trypanosomatid isolates, finding aneuploidies are ancestral and an ancient duplication is maintained in some species.

The paper performs a genome-wide RNAi screen in Trypanosoma brucei to identify cell cycle regulators, identifying hundreds of proteins involved in different stages of the cell cycle and providing functional genomic insights.