Author

Lorenzo Briganti

University of Colorado AnschutzORCID 0000-0003-2237-6896Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Assay:proteomics· 2 Research Focus:drug response / drug discovery· 1 Assay:structural biology· 1

Frequent Co-Authors

Arun S. AnnamalaiiD· 3 shared Mamuka KvaratskheliaiD· 3 shared Reed Haney· 3 shared Alan EngelmaniD· 2 shared Ashwanth Christopher FrancisiD· 2 shared Juliet Greenwood· 2 shared Satya Prakash SinghiD· 2 shared Szu‐Wei HuangiD· 2 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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3 shared papersMicrobiology

Arun S. AnnamalaiORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

MicrobiologymBioPeer-reviewedApr 15, 2025

Structural and Mechanistic Bases for Resistance of the M66I Capsid Variant to Lenacapavir

Lorenzo Briganti, Arun S. Annamalai, Stephanie M. Bester…·Mamuka Kvaratskhelia

This paper investigates how the M66I mutation in HIV-1 capsid protein confers resistance to lenacapavir by altering inhibitor binding and viral replication.

23 citationstop 1%

humanstructural biology

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MicrobiologyPLoS PathogensPeer-reviewedJan 27, 2025

The primary mechanism for highly potent inhibition of HIV-1 maturation by lenacapavir

Szu‐Wei Huang, Lorenzo Briganti, Arun S. Annamalai…·Mamuka Kvaratskhelia

This study identifies the mechanism by which lenacapavir inhibits HIV-1 maturation by altering capsid protein assembly.

26 citationstop 1%

humanproteomics

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MicrobiologymBioPeer-reviewedOct 15, 2024

The structural and mechanistic bases for the viral resistance to allosteric HIV-1 integrase inhibitor pirmitegravir

Tung Dinh, Zahira Tber, Juan S. Rey…·Mamuka Kvaratskhelia

This paper identifies the mechanism of resistance to the HIV-1 integrase inhibitor pirmitegravir and develops a more potent analog to overcome this resistance.

14 citations

humanproteomics

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