Structural and Mechanistic Bases for Resistance of the M66I Capsid Variant to Lenacapavir
Lorenzo Briganti, Arun S. Annamalai, Stephanie M. Bester, Guochao Wei, Jonathan R. Andino-Moncada, Satya Prakash Singh, Alex B. Kleinpeter, Meghna Tripathi, Binh Nguyen, Rajalingam Radhakrishnan, Parmit Kumar Singh, Juliet Greenwood, Lauren I. Schope, Reed Haney, Szu‐Wei Huang, , Mamuka Kvaratskhelia
This paper investigates how the M66I mutation in HIV-1 capsid protein confers resistance to lenacapavir by altering inhibitor binding and viral replication.
mBio · Apr 15, 2025Peer-reviewedMicrobiology