Author
California Institute of TechnologyORCID 0000-0001-9170-2283Unclaimed ORCID profile · follow to get notified of new preprints
9 papers
Recent·Most cited
Li‐En Lin, Xiaotian Bi, Adrian Colazo, Haomin Wang, Lu Wei
This paper develops a deep learning-augmented SRS imaging method to profile metabolism in live neuronal co-cultures, revealing cell-type-specific metabolic responses to various conditions.
Chemical & Biomedical Imaging · May 28, 2026Peer-reviewedNeuroscience
Rahuljeet Singh Chadha, Adrian Colazo, Joseph A. Ambarian, Ziguang Yang, Philip A. Kocheril, Benjamin Yang, Lu Wei
The paper introduces MetaboRamics, a method for 16-color metabolic imaging in live cells using stimulated Raman scattering, revealing metabolic changes in EMT and under various stress conditions.
bioRxiv · May 26, 2026 · PreprintCell Biology
Naseeb Kaur Malhi, Yingjun Luo, Muxi Chen, Xiaofang Tang, Dongqiang Yuan, Rahuljeet Singh Chadha, Alonso Tapia, Shufan Yin, Xuejing Liu, Meirigeng Qi, Marpadga A. Reddy, Jiawei Sun, James C. Otto, Lu Wei, John P. Cooke, , Zhen Bouman Chen
This study maps endothelial-macrophage interactions in diabetic vasculature using single-cell and spatial transcriptomics, identifying TREM2 as a key driver of vascular inflammation and ischemic response in diabetes.
Science Translational Medicine · Apr 22, 2026Peer-reviewedCell Biology
Rahuljeet Singh Chadha, Philip A. Kocheril, Adrian Colazo, Edmund D. Kapelczak, Berea Suen, Ziguang Yang, Tara A. TeSlaa, Lu Wei
This paper introduces MATRIX-SRS, a method to image TCA cycle activity in live cells, revealing metabolic changes during epithelial-to-mesenchymal transition.
bioRxiv · Feb 1, 2026 · PreprintBiochemistry
Xiaotian Bi, Berea Suen, Li Li Lin, Kun Miao, Lu Wei
This study uses advanced imaging techniques to analyze polyQ aggregates in live neurons, revealing their growth dynamics and compartmentalization in Huntington's Disease.
Proceedings of the National Academy of Sciences · Jan 21, 2026Peer-reviewedBiophysics
Rahuljeet Singh Chadha, Benjamin K. Yang, Dongqiang Yuan, Edmund D. Kapelczak, Philip A. Kocheril, Alonso Tapia, Shivansh Mahajan, Adrian Colazo, Naseeb Kaur Malhi, Joseph A. Ambarian, Xuejing Liu, Tara A. TeSlaa, Zhen Chen, Lu Wei
This study uses SRS microscopy to show that endothelial cells store glycogen under diabetes-like stress, which helps them survive glucose starvation and may offer new therapeutic targets for diabetes-related endothelial dysfunction.
Advanced Science · Nov 26, 2025Peer-reviewedCell Biology
Xuejing Liu, Dongqiang Yuan, Yingjun Luo, Xiaofang Tang, Alonso Tapia, Naseeb Kaur Malhi, Ting-Yun Wang, Sachchidanand Tiwari, Rahuljeet Singh Chadha, Piotr M. Swiderski, Marcin Kortylewski, Norbert Pardi, Lu Wei, Satdarshan P. Monga, Wendong Huang, , Zhen Chen
This study shows that inhibiting endothelial AGO1 reduces vascular inflammation and atherosclerosis by blocking its non-canonical nuclear role in promoting NF-κB-driven inflammation.
bioRxiv · May 1, 2025 · PreprintPhysiology
Dongkwan Lee, Haomin Wang, Philip A. Kocheril, Xiaotian Bi, Noor Naji, Lu Wei
This paper introduces WF-BonFIRE, a wide-field bond-selective fluorescence imaging technique that achieves single-molecule sensitivity and kilohertz speeds for live-cell and bacterial imaging.
Optica · Jan 7, 2025Peer-reviewedBiophysics
Chenxi Qian, Kun Miao, Li‐En Lin, Xinhong Chen, Jiajun Du, Lu Wei
This paper introduces VISTA, a label-free vibrational imaging technique that achieves high-resolution imaging of biological structures with 82 nm resolution and enables unbiased, high-throughput tissue analysis.
Nature Communications · Jun 15, 2021Peer-reviewedNeuroscience