Christopher M. Waters

This study identifies contingency loci in phages that generate genetic diversity through frameshift mutations, enabling bet-hedging against host defenses.

This study investigates the dual-function DGC/PDE DcpB in A. tumefaciens, showing its cell cycle-dependent PDE activity regulates motility and biofilm formation, with genetic interactions involving thuR.

The paper identifies Gp15, a phage DNA ejection protein that inhibits the CBASS effector CapV to evade bacterial antiviral defense.

The paper uses single-cell imaging to show phenotypic sorting and bet-hedging in Vibrio cholerae biofilms through c-di-GMP level differences.

This paper identifies and characterizes ZpdA, a zinc-regulated phosphodiesterase in V. cholerae that modulates cyclic di-GMP levels through transcriptional and post-translational zinc dependence.

The paper shows that DNA repair is critical for Vibrio cholerae growth on TCBS agar, with DNA gyrase inhibition by bile acids mimicking fluoroquinolone effects.

This study identifies a novel Type IV restriction system in V. cholerae, TgvAB, that targets glucosylated 5-hydroxymethylcytosine on phage DNA, revealing evolutionary tradeoffs in phage resistance.

This study shows that negative feedback of c-di-GMP levels in V. cholerae optimizes switching between sessile and motile lifestyles by regulating PDE expression through VpsR.

This study shows that pGpG, a byproduct of c-di-GMP degradation, regulates virulence and biofilm formation in Erwinia amylovora by affecting gene expression and amylovoran production.