Author

Shimin Le

National University of SingaporeORCID 0000-0003-2359-1897Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Approach:mechanistic / dynamical model· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Benjamin Thomas GoultiD· 1 shared Fei ShangiD· 1 shared Hu Chen· 1 shared Jasmine Fei Li ChiniD· 1 shared Jiaqing YeiD· 1 shared Jie YaniD· 1 shared Jingxing LuoiD· 1 shared Karen BakeriD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperCell Biology

Benjamin Thomas GoultORCID

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2 papers

Recent·Most cited

Cell BiologybioRxivPreprintJan 19, 2026

An Aggregation Prone Region (APR) in talin controls talin self-interactions to regulate integrin adhesion complex dynamics

Neil J. Ball, Paula Turkki, Yanyu Guo…·Benjamin Thomas Goult

This paper identifies an aggregation-prone region in talin that drives self-interactions and regulates integrin adhesion complex dynamics through mechanical unfolding and oligomerization.

DOI 10.64898/2026.01.13.699108

experimental assaycell signaling & trafficking

𝕏 PostBluesky

BiophysicsbioRxivPreprintMay 30, 2025

Mechanical Responses of the Giant Nesprin-2

Fei Shang, Y. N. Zhang, Jiaqing Ye…·Shimin Le

This study investigates the mechanical dynamics of giant nesprin-2's spectrin repeat domains under force, revealing their unfolding and refolding behavior and their role in force absorption.

DOI 10.1101/2025.05.30.657030

deep learningmechanistic / dynamical model

𝕏 PostBluesky