Author

James W.S. Jahng

Stanford Cardiovascular InstituteORCID 0000-0003-2367-6567Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2 Neuroscience· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2 Approach:statistical model· 2 Assay:ATAC-seq· 1 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

Joseph C. WuiD· 3 shared Alison Schroer Vander RoestiD· 2 shared Brock RobertsiD· 2 shared Daniel BernsteiniD· 2 shared Paul V. HeinrichiD· 2 shared Sean M. WuiD· 2 shared Soah LeeiD· 2 shared A PaascheiD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersMolecular Biology

Joseph C. WuORCID

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3 papers

Recent·Most cited

Molecular BiologybioRxivPreprintJun 6, 2026

Beta-Adrenergic Stimulation and MYH7 G256E Mutant Gene Dosage Drive Hypertrophic Cardiomyopathy Phenotype Penetrance

Paul V. Heinrich, Raina M. Jung, Jonathan Samuel Achter…·Sean M. Wu

This study investigates factors influencing HCM phenotype penetrance by comparing MYH7 mutations in isogenic hiPSC-CMs and shows that beta-adrenergic stimulation and gene dosage affect disease expression.

DOI 10.64898/2026.06.02.729411

humanbulk RNA-seq

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NeurosciencebioRxivPreprintOct 3, 2025

Age-related microbiome metabolites alter RNA splicing and chromatin accessibility in the brain

Meenakshi Chakraborty, Sophia M. Shi, Imani E. Porter…·Ami Siddharth Bhatt

The paper identifies age-related microbiome metabolites that alter RNA splicing and chromatin accessibility in the mouse brain using metabolomics, transcriptomic, and multi-omic approaches.

1 citation

mousemetabolomics

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Molecular BiologybioRxivPreprintJun 8, 2023

Multi-scale models reveal hypertrophic cardiomyopathy MYH7 G256E mutation drives hypercontractility and elevated mitochondrial respiration

Soah Lee, Alison Schroer Vander Roest, Cheavar A. Blair…·Daniel Bernstein

This study investigates the effects of the MYH7 G256E mutation on myosin function across multiple scales, finding increased hypercontractility and mitochondrial respiration.

2 citations

humanscRNA-seq

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